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pentobarbital will lessen the level or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers reduces plasma concentration of abemaciclib and its metabolites.Even though it may be used as a sedative and anticonvulsant by medical pro